Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana
نویسندگان
چکیده
The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.0]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 lM, whereas 4 has no activity. 2007 Published by Elsevier Ltd.
منابع مشابه
Five new cadinane-type sesquiterpenes from the heartwood of Chamaecyparis obtusa var. formosana.
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